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Biological Skin Renewal · Nişantaşı

Istanbul Polynucleotide
Skin Renewal, Anti-Aging

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Established
6+ Years Experience
2019
Certified Device
Alma Soprano Ice
FDA
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Plastic Surgery
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New generation biological skin renewal with Rejuran (Korea) and Plinest (Italy). Our specialist medical team, especially for under-eye and fine lines. Applied by

Book Now · +90 212 561 23 22 WhatsApp
Medically reviewed by: Our specialist medical team · Last updated:
Performed By
Plastic Surgeon + Specialist Dermatologist
Duration
30-45 Minutes
Sessions
3-4 Sessions
Brands
Rejuran + Plinest
What is Polynucleotide?

New generation biological skin renewal

When injected into the skin, it triggers cell renewal, initiates DNA-level healing, and activates the skin's own healing mechanisms. Polynucleotide is purified nucleic acid fragments obtained from salmon DNA.

Unlike fillers and mesotherapy, polynucleotide doesn't add volume — instead, it renews the skin tissue from within. It activates fibroblast cells, gradually increases collagen and elastin synthesis, and improves micro-circulation.

It has been the most popular application of the last 2 years, especially for dark under-eye circles, fine wrinkles, skin laxity, acne scars, and general skin quality. Rejuran (Korea) is the global standard, Plinest (Italy) is the European alternative.

Brands and Types Used

Polynucleotide applications offered

Each brand and type comes with specialized formulations for distinct skin needs.

01

Rejuran Healer

Korea's most popular polynucleotide product. Standard option for skin renewal. Suitable for all skin types, general anti-aging.

02

Rejuran I (Eye)

Ideal for dark circles, fine lines, and bags. Low viscosity version specially formulated for the under-eye zone.

03

Rejuran S (Scar)

Specialized formula for acne scars and atrophic scars. Effect is enhanced when combined with microneedling.

04

Rejuran HB+ (Plus)

Both renews skin tissue and provides hydration. Hyaluronic acid-enriched version.

05

Plinest (Italy)

EU CE certified safety standards. PDRN-based, European-sourced polynucleotide. Italian Mastelli company product.

06

Newest / Plinest Fast

Visible results within 2 weeks after the initially session. New generation fast-acting formula.

Process

Treatment process

Every step from consultation to result.

1

Consultation

Skin analysis, concern zone identification, suitable product selection.

2

Preparation

Skin cleaning, anesthetic cream (mandatory for under-eye), 20-minute wait.

3

Application

Micro-injections. Cannula preferred for under-eye.

4

Follow-up

Check-up and next session 2-3 weeks later. Total 3-4 sessions.

Frequently Asked Questions

Common questions

Polynucleotide is purified nucleic acid fragments obtained from salmon DNA. It triggers skin cell renewal at the DNA level. It is biocompatible and does not cause allergic reactions.
Filler adds volume, polynucleotide renews skin tissue from within. While filler provides instantly visible results, polynucleotide provides gradual and natural renewal. They serve different purposes.
Polynucleotide improves micro-circulation in the under-eye area, reduces dark circles, and softens fine lines. Unlike filler, it renews the area without adding volume. For this reason, it is considered the most suitable option for the under-eye.
After the first session, improvement in skin tone is felt. Notable changes begin after the 2nd session. 3-4 sessions are needed for full effect.
Applied with very fine needles. Comfort is enhanced with anesthetic cream. Cannula technique is preferred in sensitive areas like under-eye — less painful and lower bruising risk.
Rejuran is of Korean origin and more widely used globally. Plinest is Italian-produced, EU-standard alternative. The effect principle is similar, but formulation details differ. Selection is made by physician decision.
Mild swelling may occur 24-48 hours after application. Small bumps at injection points in the under-eye disappear within 1-3 days. Full healing takes 5-7 days.
Prices vary by product used and number of sessions. For current pricing, please call +90 212 561 23 22.
Pregnancy, breastfeeding, active skin infection, autoimmune diseases, and salmon allergy are contraindications. Full assessment is made during physician consultation.
Treatments are performed by our specialist medical team with experienced micro-injection techniques.
Yes. Authentic Allergan Botox® preparations approved by the FDA and the Turkish Ministry of Health are used. The procedure is performed solely by our specialist medical team under sterile clinical conditions.
Average duration is 4-6 months. With regularly spaced repeat sessions, the effect window can lengthen and less product is gradually required.
Initial effects appear between days 3-7, with the complete outcome visible by day 14. Daily activities resume immediately after the appointment.
During the first 4 hours, avoid lying flat and refrain from massaging the treated area. Skip intense exercise and high-heat exposure (sauna, hammam) for 24 hours. These precautions help keep the product in the target muscle.
Aesthetic: Dynamic facial wrinkles (glabellar lines, crow's feet, forehead lines), masseter hypertrophy, hyperhidrosis
When the correct dose is delivered to the correct anatomical landmarks, the risk of side effects is low. Brief redness or a small bruise may occur. Treatment by a Plastic Surgeon further reduces these risks.
Yes. A specialized "Brotox" protocol is applied for male anatomy and muscle structure. The aim is natural, light line preservation — never a frozen or artificial look.
Medical skin care is delivered under Plastic Surgeon supervision using clinical-grade devices (HydraFacial, microneedling, PRP) and active-ingredient products. Unlike a routine facial, it offers therapeutic solutions for acne, pigmentation, and wrinkles.
Depending on the skin concern, 1-6 sessions are typically planned. HydraFacial shows results from the first visit; for acne or pigmentation, 4-6 sessions are advised. Sessions are spaced 2-4 weeks apart.
Yes. Low-intensity protocols are prepared specifically for sensitive skin. Following the skin analysis, the appropriate product–device combination is determined by the Plastic Surgeon.
For oily and acne-prone skin, HydraFacial paired with dermapen is preferred. For dry skin, a skin booster plus mesotherapy works well. Pigmented skin responds to chemical peeling combined with PRP. For anti-ageing, PRP with exosome is recommended.
After most treatments, daily life resumes immediately. Non-invasive procedures such as HydraFacial allow social activity right away. Light redness may persist for 24-48 hours after microneedling.
Yes, although sun protection becomes essential. Laser and peeling protocols are preferred during autumn and winter. HydraFacial and exosome procedures can be performed safely throughout the year.
Age 25 is the ideal starting point for preventive care. Acne management is offered from 16+, and anti-ageing protocols from 30+. A personalised plan follows the skin analysis.
Exosomes are nano-scale bioactive vesicles released by stem cells. Their growth factor, microRNA, and protein content supports skin regeneration and hair follicle revitalisation.
For skin, 3-4 sessions are planned; for hair, 4-6 sessions are recommended. Sessions are 2-4 weeks apart. The first noticeable change is felt around the second session, while the lasting result becomes clear from month 3.
Exosomes carry 100-200 times more growth factors than PRP and produce faster, more pronounced results. Depending on budget and skin status, a combined approach is also a valid option.
Yes. The products are manufactured to GMP standards and are sterile and allergen-free. Because they replicate the body's natural repair process, the side effect profile is very low.
Strong outcomes are seen in hair loss, thinning or sparse hair, facial ageing, fine lines, post-acne scars, loss of skin tone, and under-eye hollowing.
A topical anaesthetic cream is applied prior to the treatment. Delivered through microneedling or injection, the procedure is described by the majority of patients as a mild tingling rather than pain.
A single session lasts 6-9 months. The full protocol (3-4 sessions) extends the result to 12-18 months. The outcome is maintained with 1-2 yearly top-up sessions.
— BOTOX —
— MEDICAL SKIN CARE —
— EXOSOME THERAPY —

Contact us for consultation

You can book an appointment to learn more around the procedure suitable for you.

Book: +90 212 561 23 22 WhatsApp
⚕ Medical Disclaimer The information on this page is for general informational purposes only and does not constitute medical advice. Indications, dosages, and outcomes may vary between individuals. Before any aesthetic treatment, please schedule a free skin analysis and medical consultation at our clinic.

🌟 Our Popular Treatments

Polynucleotide PN-HPT Process

  1. 🔬 Skin Age Analysis: Skin elasticity and aging level determined.
  2. 🧬 PN-HPT Prep: High Purity Technology salmon DNA-derived polynucleotides.
  3. 💉 Microinjection: Mesogun or manual. Face, neck, décolleté.
  4. ⏱️ Result: 3-4 sessions, 2 weeks apart. 8-12 month effect — DNA-level regeneration.

Why Polynucleotide at Veneta Aesthetics Clinic®?

🛡️ Polynucleotide Safety

CE approved salmon-derived PN-HPT. Side effects: minimal redness 24h. High purity (>99.5%). Pregnancy, allergy, active infection contraindicated.